Why Myrbetriq?

What is MYRBETRIQ? MYRBETRIQ is a prescription medicine for adults that can be used alone or with solifenacin succinate to treat the following symptoms due to a condition called overactive bladder:

• Urge urinary incontinence: a strong need to urinate with leaking or wetting accidents
• Urgency: a strong need to urinate right away
• Frequency: urinating often

How should I take MYRBETRIQ

• If your doctor prescribes MYRBETRIQ and solifenacin succinate together, you should take 1 MYRBETRIQ tablet and 1 solifenacin tablet at the same time, 1 time a day.
• You should take MYRBETRIQ with water and swallow the tablet whole.
• Do not chew, break, or crush the tablet.
• You can take MYRBETRIQ with or without food.
• You can take MYRBETRIQ and solifenacin succinate together with or without food.
• If you miss a dose of MYRBETRIQ tablets, take it as soon as possible. If it has been more than 12 hours since taking the last dose of MYRBETRIQ tablets, skip that dose and take the next dose at the usual time.
• If you take too much MYRBETRIQ tablets, call your doctor or go to the nearest hospital emergency room right away.

The most common side effects of MYRBETRIQ, when used with solifenacin succinate, include:

• dry mouth
• urinary tract infection
• constipation
• fast heartbeat

USE OF MYRBETRIQ MYRBETRIQ^® (mirabegron extended-release tablets) is a prescription medicine for adults that can be used alone or with solifenacin succinate to treat overactive bladder (OAB) with symptoms of urgency, frequency and leakage.

IMPORTANT SAFETY INFORMATION FOR MYRBETRIQ Do not take MYRBETRIQ if you are allergic to mirabegron or any ingredients in MYRBETRIQ.

MYRBETRIQ may cause your blood pressure to increase or make your blood pressure worse if you have a history of high blood pressure. You and your doctor should check your blood pressure while you are taking MYRBETRIQ. Call your doctor if you have increased blood pressure.

MYRBETRIQ may increase your chances of not being able to empty your bladder. Tell your doctor right away if you have trouble emptying your bladder or if you have a weak urine stream.

MYRBETRIQ may cause an allergic reaction with swelling of the face, lips, throat or tongue with or without difficulty breathing. Stop using MYRBETRIQ tablets and go to the nearest hospital emergency room right away.

Tell your doctor about all the medicines you take including medications for overactive bladder or other medicines especially thioridazine (Mellaril™ and Mellaril-S™), flecainide (Tambocor^®), propafenone (Rythmol^®), digoxin (Lanoxin^®), or solifenacin succinate (VESIcare^®). MYRBETRIQ may affect the way other medicines work, and other medicines may affect how MYRBETRIQ works.

Before taking MYRBETRIQ, tell your doctor about all of your medical conditions, including if you have liver or kidney problems.

The most common side effects of MYRBETRIQ include high blood pressure, pain or swelling of the nose or throat (nasopharyngitis), urinary tract infection, and headache.

The most common side effects of MYRBETRIQ, when used with solifenacin succinate, include dry mouth, urinary tract infection, constipation, and fast heartbeat.

Please refer to the solifenacin succinate Patient Product Information and complete Prescribing Information when taking in combination with MYRBETRIQ.

For further information, please talk to your healthcare professional and see accompanying Patient Product Information and complete Prescribing Information for MYRBETRIQ^® (mirabegron extended‑release tablets).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

Myrbetriq, Astellas, and the flying star logo are registered trademarks of Astellas Pharma Inc. All other trademarks or registered trademarks are the property of their respective owners.